E-ISSN 2146-8362 |
 

Original Research Open Access


Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma

Samina Zaheer, Abdul Hannan Nagi.

Abstract
Objectives: Mammary serine protease inhibitor (MASPIN) has numerous interactions with tumor pathogenesis and progression. Its relationships with apoptosis and angiogenesis have proven the impact on prognosis. However, its exact role is not known and needs further work in relation to various human cancers. Current study was planned to investigate the subcellular expression of MASPIN in oral squamous cell carcinoma (OSCC) and to observe its relation with tumor grade.
Methods: It was a descriptive study, conducted at the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. Histological diagnosis of squamous cell carcinoma was confirmed in 50 cases, and expression of MASPIN was determined by avidinbiotin-peroxidase complex method of immunohistochemical staining. MASPIN expression was scored on the basis of intensity of staining and the percentage of the cells that stained positively. Data was analyzed with SPSS using appropriate statistical procedures.
Results: Mean age of the patients was 56.84 ± 1.58 years with male to female ratio 1.3:1. All tumors were locally advancing (Stage III). Histologically, 58% tumors were Grade 1, other grades were less common. MASPIN expression was observed in 32 (64%) cases, and it was localized to the cytoplasm of the tumor cells in all cases. Among the positive cases, its expression was focal in 15 (44.1%), diffuse but moderate in 13 (38.2%) and diffuse and intense in 6(17.7%) cases. MASPIN expression was significantly associated (P: 0.043) and negatively correlated (P: 0.034) with tumor grade.
Conclusions: MASPIN expression was observed in the majority of OSCC. However, it was localized to the cytoplasm of tumor cells in all cases. Loss of MASPIN expression was observed more frequently in poorly differentiated cancers.

Key words: Mammary serine protease inhibitor, oral cancer, squamous cell carcinoma, tumor grade


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Samina Zaheer
Articles by Abdul Hannan Nagi
on Google
on Google Scholar
Article Statistics
 Viewed: 1015
Downloaded: 330
Cited: 0

REFERENCES
1. Lara H, Wang Y, Beltran AS, Juárez-Moreno K, Yuan X, Kato S, et al. Targeting serous epithelial ovarian cancer with designer zinc finger transcription factors. J Biol Chem 2012;287:29873-86. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
2. Berardi R, Morgese F, Onofri A, Mazzanti P, Pistelli M, Ballatore Z, et al. Role of maspin in cancer. Clin Transl Med 2013;2:8. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
3. Tsui KH, Wang SW, Chung LC, Feng TH, Lee TY, Chang PL, et al. Mechanisms by which interleukin-6 attenuates cell invasion and tumorigenesis in human bladder carcinoma cells. Biomed Res Int 2013;2013:791212. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
4. Endsley MP, Hu Y, Deng Y, He X, Warejcka DJ, Twining SS, et al. Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion. J Biol Chem 2011;286:24599-607. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Jiang N, Meng Y, Zhang S, Mensah-Osman E, Sheng S. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene 2002;21:4089-98. [DOI via Crossref]    [Pubmed]   
6. Huang Y, Cai LW, Yang R. Expression of maspin in the early pregnant mouse endometrium and its role during embryonic implantation. Comp Med 2012;62:179-84. [Pubmed]    [PMC Free Fulltext]   
7. Bascones-MartĂ­nez A, LĂłpez-Durán M, Cano-Sánchez J, Sánchez- Verde L, DĂ­ez-RodrĂ­guez A, Aguirre-EchebarrĂ­a P, et al. Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans. Oncol Lett 2012;3:1319-1325. [Pubmed]    [PMC Free Fulltext]   
8. Marioni G, Gaio E, Giacomelli L, Bertolin A, D’Alessandro E, Stramare R, et al. MASPIN subcellular localization and expression in oral cavity squamous cell carcinoma. Eur Arch Otorhinolaryngol 2008;265 Suppl 1:S97-104. [DOI via Crossref]    [Pubmed]   
9. Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN, Mymryk JS, et al. Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest 2011;91:1181-7. [DOI via Crossref]    [Pubmed]   
10. Choi KY, Choi HJ, Chung EJ, Lee DJ, Kim JH, Rho YS. Loss of heterozygosity in mammary serine protease inhibitor (maspin) and p53 at chromosome 17 and 18 in oral cavity squamous cell carcinoma. Head Neck 2014. [DOI via Crossref]   
11. Warnakulasuriya S. Prognostic and predictive markers for oral squamous cell carcinoma: The importance of clinical, pathological and molecular markers. Saudi J Med Med Sci 2014;2:12. [DOI via Crossref]   
12. Iezzi G, Piattelli A, Rubini C, Goteri G, Artese L, Perrotti V, et al. Maspin expression in oral squamous cell carcinoma. J Craniofac Surg 2007;18:1039-43. [DOI via Crossref]    [Pubmed]   
13. Zhang L, Tang ZG, Zhou ZG, Tong XJ, Li XL. The expression of Maspin and VEGF gene in oral squamous cell carcinoma and its significance. Shanghai Kou Qiang Yi Xue 2005;14:557-60. [Pubmed]   
14. Luo J, Shu HR, Ying YK, Wu WL, Ji T, Zhong LP. Mammary serine proteinase inhibitor subcellular expression in oral squamous cell carcinoma and its clinical significance. Zhonghua Kou Qiang Yi Xue Za Zhi 2011;46:505-9. [Pubmed]   
15. Marioni G, Staffieri C, Staffieri A, De Filippis C, Blandamura S. MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: Emerging evidence and therapeutic perspectives. Acta Otolaryngol 2009;129:476-80. [DOI via Crossref]    [Pubmed]   
16. Yasumatsu R, Nakashima T, Hirakawa N, Kumamoto Y, Kuratomi Y, Tomita K, et al. Maspin expression in stage I and II oral tongue squamous cell carcinoma. Head Neck 2001;23:962-6. [DOI via Crossref]    [Pubmed]   
17. Xia W, Lau YK, Hu MC, Li L, Johnston DA, Sheng Sj, et al. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. Oncogene 2000;19:2398-403. [DOI via Crossref]    [Pubmed]   
18. Mhawech-Fauceglia P, Dulguerov P, Beck A, Bonet M, Allal AS. Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy. J Clin Pathol 2007;60:185-9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
19. Vered M, Allon I, Dayan D. Maspin, p53, p63, and Ki-67 in epithelial lesions of the tongue: From hyperplasia through dysplasia to carcinoma. J Oral Pathol Med 2009;38:314-20. [DOI via Crossref]    [Pubmed]   
20. Shui HH, Luo L, Liang SZ, Huang L, Li W. The expression of Maspin protein in oral squamous cell carcinoma and its significance. Hua Xi Kou Qiang Yi Xue Za Zhi 2008;26:604-6, 610. [Pubmed]   
21. Fontes A, de Sousa SM, dos Santos E, Martins MT. The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis. J Cutan Pathol 2009;36:1151-6. [DOI via Crossref]    [Pubmed]   
22. Xu C, Quddus MR, Sung CJ, Steinhoff MM, Zhang C, Lawrence WD. Maspin expression in CIN 3, microinvasive squamous cell carcinoma, and invasive squamous cell carcinoma of the uterine cervix. Mod Pathol 2005;18:1102-6. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Zaheer S, Nagi AH. Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. J Interdiscipl Histopathol. 2014; 2(4): 213-216. doi:10.5455/jihp.20141029023315


Web Style

Zaheer S, Nagi AH. Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. http://www.jidhp.com/?mno=164309 [Access: January 23, 2018]. doi:10.5455/jihp.20141029023315


AMA (American Medical Association) Style

Zaheer S, Nagi AH. Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. J Interdiscipl Histopathol. 2014; 2(4): 213-216. doi:10.5455/jihp.20141029023315



Vancouver/ICMJE Style

Zaheer S, Nagi AH. Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. J Interdiscipl Histopathol. (2014), [cited January 23, 2018]; 2(4): 213-216. doi:10.5455/jihp.20141029023315



Harvard Style

Zaheer, S. & Nagi, A. H. (2014) Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. J Interdiscipl Histopathol, 2 (4), 213-216. doi:10.5455/jihp.20141029023315



Turabian Style

Zaheer, Samina, and Abdul Hannan Nagi. 2014. Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. Journal of Interdisciplinary Histopathology, 2 (4), 213-216. doi:10.5455/jihp.20141029023315



Chicago Style

Zaheer, Samina, and Abdul Hannan Nagi. "Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma." Journal of Interdisciplinary Histopathology 2 (2014), 213-216. doi:10.5455/jihp.20141029023315



MLA (The Modern Language Association) Style

Zaheer, Samina, and Abdul Hannan Nagi. "Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma." Journal of Interdisciplinary Histopathology 2.4 (2014), 213-216. Print. doi:10.5455/jihp.20141029023315



APA (American Psychological Association) Style

Zaheer, S. & Nagi, A. H. (2014) Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma. Journal of Interdisciplinary Histopathology, 2 (4), 213-216. doi:10.5455/jihp.20141029023315





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscipl Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscipl Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscipl Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscipl Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscipl Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscipl Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscipl Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscipl Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 15 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscipl Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscipl Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscipl Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscipl Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscipl Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839
    Cited : 2 times [Click to see citing articles]

  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma
    Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou
    J Interdiscipl Histopathol. 2014; 2(3): 135-144
    » Abstract & References » doi: 10.5455/jihp.20140429121735
    Cited : 2 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscipl Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 2 times [Click to see citing articles]

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701
    Cited : 2 times [Click to see citing articles]