E-ISSN 2146-8362 |
 

Original Research Open Access


Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

Neveen M. El-Sherif, Noha Mohy Issa.

Cited by (1)

Abstract
Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat.
Materials and Methods: 25 animals were divided into three groups: Group I (Control group), Group II (NA treated group) received NA at a dose of 200 mg/kg/day dissolved in 5 ml/kg corn oil orally by gastric tube, Group III (protected group) received rosemary extract (10 ml/kg/day) followed after 60 min by NA at the same previous dose orally by gastric tube. The experiment lasted 30 days. The following parameters were studied: Biochemical assessment of renal function, histological, immunohistochemical, morphometric studies and statistical analysis of the results.
Results: NA treatment resulted in a highly significant increase in the mean values of serum urea and creatinine. NA induced histological changes in the form of glomerular congestion. Some glomeruli demonstrated marked mesangial expansion and hence that Bowman’s spaces were almost completely obliterated. Shrinkage of renal glomeruli with widening of Bowman’s spaces could also be seen. Focal tubular dilatation with appearance of casts inside the tubules was observed. Congested peritubular blood vessels and interstitial hemorrhage were also seen. The medullary region demonstrated vascular congestion and fibrosis. Focal cellular infiltration was presented in the interstitium. The renal cortex of NA treated rats showed a noticeable down regulation in alkaline phosphatase positive immunoreactive cells in some proximal convoluted tubules. NA induced up regulation of positive immunoreaction for inducible nitric oxide synthase in the proximal and distal convoluted tubules as well as in the collecting tubules. All previous results were significantly reversed in the protected group compared with NA treated group.
Conclusions: It is concluded that NA has a harmful effect on rat kidney. Rosemary extract had a protective role against renal injury induced by NA and this effect may be attributed to its antioxidant and anti-inflammatory activity.

Key words: Keywords: Naphthalene, tobacco smoke, rosemary, iNOS, alkaline phosphatase


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Neveen M. El-Sherif
Articles by Noha Mohy Issa
on Google
on Google Scholar
Article Statistics
 Viewed: 1228
Downloaded: 413
Cited: 1

REFERENCES
1. Ding X, Kaminsky LS. Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 2003;43:149-73. [DOI via Crossref]    [Pubmed]   
2. Preuss R, Drexler H, Böttcher M, Wilhelm M, BrĂĽning T, Angerer J. Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries. Int Arch Occup Environ Health 2005;78:355-62. [DOI via Crossref]    [Pubmed]   
3. Zhang Q, Adiseshaiah P, Reddy SP. Matrix metalloproteinase/ epidermal growth factor receptor/mitogen-activated protein kinase signaling regulate fra-1 induction by cigarette smoke in lung epithelial cells. Am J Respir Cell Mol Biol 2005;32:72-81. [DOI via Crossref]    [Pubmed]   
4. Witschi H, Espiritu I, Maronpot RR, Pinkerton KE, Daniel JA. The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis 1997;18:2035-42. [DOI via Crossref]    [Pubmed]   
5. Grimm AC, Harwood CS. Chemotaxis of Pseudomonas sp. To the polyaromatic hydrocarbon naphthalene. Appl Environ Microbiol 1997;63:4111-5. [Pubmed]    [PMC Free Fulltext]   
6. Kumar V, Abbas A, Fausto N. Robbins & Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Inc., Saunders; 2004. p. 955-1021.
7. Hazardous Substances Data Bank (HSDB, 2003). Bethesda, MD: National Library of Medicine. Last revision date for naphthalene summary listed as 03/05/2003. Available from: http://www.sis.nlm. nih.gov.
8. Okernatughba PO, Ezeronye OU. Petroleum degrading potential of single and mixed microbial cultures isolated from rivers in Nigeria. J Biotechnol 2003;2:288-92.
9. Preuss R, Angerer J, Drexler H. Naphthalene – An environmental and occupational toxicant. Int Arch Occup Environ Health 2003;76:556-76. [DOI via Crossref]    [Pubmed]   
10. Oliver JR, Kushwah R, Wu J, Cutz E, Yeger H, Waddell TK, et al. Gender differences in pulmonary regenerative response to naphthalene-induced bronchiolar epithelial cell injury. Cell Prolif 2009;42:672-87. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Pandya U, Saini MK, Jin GF, Awasthi S, Godley BF, Awasthi YC. Dietary curcumin prevents ocular toxicity of naphthalene in rats. Toxicol Lett 2000;115:195-204. [DOI via Crossref]   
12. Bagchi M, Balmoori J, Ye X, Bagchi D, Ray SD, Stohs SJ. Protective effect of melatonin on naphthalene-induced oxidative stress and DNA damage in cultured macrophage J774A.1 cells. Mol Cell Biochem 2001;221:49-55. [DOI via Crossref]    [Pubmed]   
13. International Agency for Research on Cancer (IARC). Naphthalene in IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon: IARC; 2002.
14. Fu Y, Zu Y, Chen L, Shi X, Wang Z, Sun S, et al. Antimicrobial activity of clove and rosemary essential oils alone and in combination. Phytother Res 2007;21:989-94. [DOI via Crossref]    [Pubmed]   
15. Haloui M, Louedec L, Michel JB, Lyoussi B. Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea. J Ethnopharmacol 2000;71:465-72. [DOI via Crossref]   
16. Cheung S, Tai J. Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis. Oncol Rep 2007;17:1525-31. [DOI via Crossref]   
17. Altinier G, Sosa S, Aquino RP, Mencherini T, Della Loggia R, Tubaro A. Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L. J Agric Food Chem 2007;55:1718-23. [DOI via Crossref]    [Pubmed]   
18. Atsumi T, Tonosaki K. Smelling lavender and rosemary increases freer radicals scavenging activity and decreases cortisol level in saliva. Psychiatry Res 2007;150:89-96. [DOI via Crossref]    [Pubmed]   
19. Stohs SJ, Ohia S, Bagchi D. Naphthalene toxicity and antioxidant nutrients. Toxicology 2002;180:97-105. [DOI via Crossref]   
20. Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. 6th ed. New York: Churchill Livingstone; 2008.
21. Drury RA, Wallington EA. Carleton Histological Techniques. 5th ed. New York: Oxford University Press; 1990. p. 279-313.
22. Mould RF. Introductory Medical Statistics. 3rd ed. Bristol, Philadelphia: Adam Hilger; 1999. p. 22-126.
23. Cotran RS, Kumar V, Robbins SL. Robbins Pathologic Basis of the Disease. 5th ed. Philadelphia. London, Toronto: W. B. Saunders Co.; 1994. [Pubmed]   
24. Alderson NL, Chachich ME, Frizzell N, Canning P, Metz TO, Januszewski AS, et al. Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat. Diabetologia 2004;47:1385-95. [DOI via Crossref]    [Pubmed]   
25. Quezada C, AlarcĂłn S, Jaramillo C, Mu-oz D, OyarzĂşn C, San MartĂ­n R. Targeting adenosine signaling to treatment of diabetic nephropathy. Curr Drug Targets 2013;14:490-6. [DOI via Crossref]    [Pubmed]   
26. Markowitz GS, Radhakrishnan J, Kambham N, Valeri AM, Hines WH, D'Agati VD. Lithium nephrotoxicity: A progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol 2000;11:1439-48. [Pubmed]   
27. Saadi L, Lebaili N, Benyoussi M. Exploration of cytotoxic effect of malathion on some rat organs structure. Commun Agric Appl Biol Sci 2008;73:875-81. [Pubmed]   
28. Comstock TJ. Renal disorder. In: Koda Kimple MA, Young LY, editors. Applied Therapeutic: The Clinical Use of Drugs. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 23-9.
29. Nashwa F, Rehab A. Sex differences in bronchiolar epithelial injury and repair following naphthalene inhalation in albino rats: A possible role of inducible nitric oxide. Egypt J Histol 2012;3:672-83.
30. Wu H, Wang Y, Tay YC, Zheng G, Zhang C, Alexander SI, et al. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney Int 2005;67:2178-86. [DOI via Crossref]    [Pubmed]   
31. Shirota K, Masaki T, Kitada H, Yanagi M, Ikeda Y, Une Y, et al. Renal glomerular fibrosis in two pigs. Vet Pathol 1995;32:236-41. [DOI via Crossref]    [Pubmed]   
32. Ellis DA, William EH, Patrick N. Pediatric Nephrology. Philadelphia: Lippincot Williams & Wilkins; 2003.
33. Masuda Y, Shimizu A, Kataoka M, Arai T, Ishikawa A, Du X, et al. Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis. Lab Invest 2010;90:1468-81. [DOI via Crossref]    [Pubmed]   
34. Mohamed SA, Elsharkawy SA. Histological study of early and late nephrotoxicity and endothelial cytotoxicity of ionic and non-ionic contrast media. Egypt J Anat 2005;18:115-32.
35. Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology 2007;15:252-9. [DOI via Crossref]    [Pubmed]   
36. Alessandrini F, Weichenmeier I, van Miert E, Takenaka S, Karg E, Blume C, et al. Effects of ultrafine particles-induced oxidative stress on Clara cells in allergic lung inflammation. Part Fibre Toxicol 2010;7:11. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
37. Belvisi M, Barnes PJ, Larkin S, Yacoub M, Tadjkarimi S, Williams TJ, et al. Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur J Pharmacol 1995;283:255-8. [DOI via Crossref]   
38. Welsh GI, Saleem MA. The podocyte cytoskeleton – Key to a functioning glomerulus in health and disease. Nat Rev Nephrol 2011;8:14-21. [DOI via Crossref]    [Pubmed]   
39. Akhgari M, Abdollahi M, Kebryaeezadeh A, Hosseini R, Sabzevari O. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum Exp Toxicol 2003;22:205-11. [DOI via Crossref]    [Pubmed]   
40. Barouki R, Morel Y. Repression of cytochrome P450 1A1 gene expression by oxidative stress: Mechanisms and biological implications. Biochem Pharmacol 2001;61:511-6. [DOI via Crossref]   
41. Gwinner W, Gröne HJ. Role of reactive oxygen species in glomerulonephritis. Nephrol Dial Transplant 2000;15:1127-32. [DOI via Crossref]    [Pubmed]   
42. Lebrecht D, Setzer B, Rohrbach R, Walker UA. Mitochondrial DNA and its respiratory chain products are defective in doxorubicin nephrosis. Nephrol Dial Transplant 2004;19:329-36. [DOI via Crossref]    [Pubmed]   
43. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003;552:335-44. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
44. Alfaro-Lira S, Pizarro-Ortiz M, Calaf GM. Malignant transformation of rat kidney induced by environmental substances and estrogen. Int J Environ Res Public Health 2012;9:1630-48. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
45. Patrakka J, Tryggvason K. Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun 2010;396:164-9. [DOI via Crossref]    [Pubmed]   
46. Raškovic A, Milanovic I, Pavlovic N, Cebovic T, Vukmirovic S, Mikov M. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Altern Med 2014;14:225. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
47. Sakr SA, Lamfon HA. Protective effect of rosemary (Rosmarinus officinalis) leaves extract on carbon tetrachloride-induced nephrotoxicity in albino rats. Life Sci J 2012;9:779-85.
48. Mulinacci N, Innocenti M, Bellumori M, Giaccherini C, Martini V, Michelozzi M. Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: An HPLC/DAD/MS study. Talanta 2011;85:167-76. [DOI via Crossref]    [Pubmed]   
49. Erkan N, Ayranci G, Ayranci E. Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chem 2008;110:76-82. [DOI via Crossref]    [Pubmed]   
50. Al Sheyab F, Abuharfeil, L Awad D. The effect of rosemary (Rosmarinus officinalis. L) plant extracts on the immune response and lipid profile in mice. J Biol 2012;3:1-22.
51. Marzieh Z, Saeed C, Saeed H, Akbar H. The study of 24 h post treatment effects of the aqueous extract of Rosmarinus officinalis after renal ischemia/reperfusion in rat. J Phys 2012;2:12-9.
52. Bozin B, Mimica-Dukic N, Samojli K. Antimicrobial and antioxidant properties of rosemary and age. Essential oils. J Agric Food Chem 2007;57:879-7885.
53. Rasoulian B, Jafari M, Noroozzadeh A, Mehrani H, Wahhab-Aghai H, Hashemi-Madani SM, et al. Effects of ischemia-reperfusion on rat renal tissue antioxidant systems and lipid peroxidation. Acta Med 2008;46:353-436.

This Article Cited By the following articles

Prevention of Nephropathy by Some Natural Sources of Antioxidants
YM 2017; 01(04): 235.

1
 

How to Cite this Article
Pubmed Style

El-Sherif NM, Issa NM. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. J Interdiscipl Histopathol. 2015; 3(1): 24-32. doi:10.5455/jihp.20150213020636


Web Style

El-Sherif NM, Issa NM. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. http://www.jidhp.com/?mno=176184 [Access: January 23, 2018]. doi:10.5455/jihp.20150213020636


AMA (American Medical Association) Style

El-Sherif NM, Issa NM. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. J Interdiscipl Histopathol. 2015; 3(1): 24-32. doi:10.5455/jihp.20150213020636



Vancouver/ICMJE Style

El-Sherif NM, Issa NM. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. J Interdiscipl Histopathol. (2015), [cited January 23, 2018]; 3(1): 24-32. doi:10.5455/jihp.20150213020636



Harvard Style

El-Sherif, N. M. & Issa, N. M. (2015) Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. J Interdiscipl Histopathol, 3 (1), 24-32. doi:10.5455/jihp.20150213020636



Turabian Style

El-Sherif, Neveen M., and Noha Mohy Issa. 2015. Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. Journal of Interdisciplinary Histopathology, 3 (1), 24-32. doi:10.5455/jihp.20150213020636



Chicago Style

El-Sherif, Neveen M., and Noha Mohy Issa. "Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat." Journal of Interdisciplinary Histopathology 3 (2015), 24-32. doi:10.5455/jihp.20150213020636



MLA (The Modern Language Association) Style

El-Sherif, Neveen M., and Noha Mohy Issa. "Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat." Journal of Interdisciplinary Histopathology 3.1 (2015), 24-32. Print. doi:10.5455/jihp.20150213020636



APA (American Psychological Association) Style

El-Sherif, N. M. & Issa, N. M. (2015) Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat. Journal of Interdisciplinary Histopathology, 3 (1), 24-32. doi:10.5455/jihp.20150213020636





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscipl Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscipl Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscipl Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscipl Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscipl Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscipl Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscipl Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscipl Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 15 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscipl Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscipl Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscipl Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscipl Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscipl Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839
    Cited : 2 times [Click to see citing articles]

  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma
    Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou
    J Interdiscipl Histopathol. 2014; 2(3): 135-144
    » Abstract & References » doi: 10.5455/jihp.20140429121735
    Cited : 2 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscipl Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 2 times [Click to see citing articles]

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701
    Cited : 2 times [Click to see citing articles]