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Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue

Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy.

Abstract
Objective. The aim of the present study was to assess Cox-2 expression in uterine serous carcinoma (USC) tissue, to correlate it with clinicopathological prognostic factors in order to assess whether selective Cox-2 inhibitors may be effective in the treatment in this tumor.
Material and methods. Cox-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 03 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients
Results. The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6%) USC specimens and a high score in 6 (19.4%) of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed.
Conclusion. Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical Cox-2 staining parameters in USC tissue and clinicopathological prognostic factors, this aggressive tumor is not a candidate for the use of selective Cox-2 inhibitors.
Key words: Cox-2 expression, uterine carcinosarcoma, clinicopathological prognostic factors

Key words: Cox-2 expression, uterine carcinosarcoma, clinicopathological prognostic factors


 
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How to Cite this Article
Pubmed Style

Menczer J, Schreiber L, Berger E, Levy T. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. J Interdiscipl Histopathol. 2016; 4(1): 9-12. doi:10.5455/jihp.20150923115314


Web Style

Menczer J, Schreiber L, Berger E, Levy T. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. http://www.jidhp.com/?mno=200051 [Access: January 23, 2018]. doi:10.5455/jihp.20150923115314


AMA (American Medical Association) Style

Menczer J, Schreiber L, Berger E, Levy T. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. J Interdiscipl Histopathol. 2016; 4(1): 9-12. doi:10.5455/jihp.20150923115314



Vancouver/ICMJE Style

Menczer J, Schreiber L, Berger E, Levy T. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. J Interdiscipl Histopathol. (2016), [cited January 23, 2018]; 4(1): 9-12. doi:10.5455/jihp.20150923115314



Harvard Style

Menczer, J., Schreiber, L., Berger, E. & Levy, T. (2016) Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. J Interdiscipl Histopathol, 4 (1), 9-12. doi:10.5455/jihp.20150923115314



Turabian Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. 2016. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. Journal of Interdisciplinary Histopathology, 4 (1), 9-12. doi:10.5455/jihp.20150923115314



Chicago Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. "Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue." Journal of Interdisciplinary Histopathology 4 (2016), 9-12. doi:10.5455/jihp.20150923115314



MLA (The Modern Language Association) Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. "Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue." Journal of Interdisciplinary Histopathology 4.1 (2016), 9-12. Print. doi:10.5455/jihp.20150923115314



APA (American Psychological Association) Style

Menczer, J., Schreiber, L., Berger, E. & Levy, T. (2016) Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue. Journal of Interdisciplinary Histopathology, 4 (1), 9-12. doi:10.5455/jihp.20150923115314





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