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Case Report Open Access


Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type

Sarala Ravindran, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, Yip Cheng Har.

Abstract
We present a rare distinctive variant of invasive carcinoma of breast characterized by adnexal differentiation of tumor of trichoblastic type. The neoplasm was identified in a mastectomy specimen from an 83-year-old Chinese woman. Morphologically, the trichoblastic differentiation was characterized by the formation of solid sheets and nests of basaloid cells. The tumor cells were positive for cytokeratin 5/6, BER-EP4, bcl-2, and β-catenin. Stromal cells were positive for CD10. The tumor cells exhibited a “triple negative” profile; the nuclei did not react with antibodies to estrogen and progesterone receptors but failed to show overexpression of the HER2/neu protein. The MIB-1 labeling index averaged 20%. It is hoped that this case increases awareness for this unique morphological variant of invasive ductal carcinoma.

Key words: Breast carcinoma, adnexal differentiation, trichoblastic


 
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How to Cite this Article
Pubmed Style

Ravindran S, Rajadurai P, Daniel JM, Har YC. Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. J Interdiscipl Histopathol. 2016; 4(2): 48-51. doi:10.5455/jihp.20160412114319


Web Style

Ravindran S, Rajadurai P, Daniel JM, Har YC. Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. http://www.jidhp.com/?mno=216834 [Access: January 23, 2018]. doi:10.5455/jihp.20160412114319


AMA (American Medical Association) Style

Ravindran S, Rajadurai P, Daniel JM, Har YC. Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. J Interdiscipl Histopathol. 2016; 4(2): 48-51. doi:10.5455/jihp.20160412114319



Vancouver/ICMJE Style

Ravindran S, Rajadurai P, Daniel JM, Har YC. Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. J Interdiscipl Histopathol. (2016), [cited January 23, 2018]; 4(2): 48-51. doi:10.5455/jihp.20160412114319



Harvard Style

Ravindran, S., Rajadurai, P., Daniel, J. M. & Har, Y. C. (2016) Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. J Interdiscipl Histopathol, 4 (2), 48-51. doi:10.5455/jihp.20160412114319



Turabian Style

Ravindran, Sarala, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, and Yip Cheng Har. 2016. Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. Journal of Interdisciplinary Histopathology, 4 (2), 48-51. doi:10.5455/jihp.20160412114319



Chicago Style

Ravindran, Sarala, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, and Yip Cheng Har. "Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type." Journal of Interdisciplinary Histopathology 4 (2016), 48-51. doi:10.5455/jihp.20160412114319



MLA (The Modern Language Association) Style

Ravindran, Sarala, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, and Yip Cheng Har. "Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type." Journal of Interdisciplinary Histopathology 4.2 (2016), 48-51. Print. doi:10.5455/jihp.20160412114319



APA (American Psychological Association) Style

Ravindran, S., Rajadurai, P., Daniel, J. M. & Har, Y. C. (2016) Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type. Journal of Interdisciplinary Histopathology, 4 (2), 48-51. doi:10.5455/jihp.20160412114319





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