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Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf

Felix M Onyije, Vivian C Zenebo, Julius K Bankole, kester A Digban, Godwin O Avwioro.

Abstract
Background: The use of Carica papaya leaves for medicines and food in our rural areas is rampant, this is due to its availability and testimonies of its efficacy. Objective: This study was aimed at investigating the activities of C. papaya on the histo-architecture of some organs.
Materials and Methods: About 20 Wistar rats were randomly divided into 4 groups of 5 each and received tap water, 2.5, 5, and 7.5 g/kg of ethanolic extract of C. papaya PO once a day for 14 days after which biochemical analyses was performed on the blood samples. The tissues were examined histologically.
Results: Albumin was significantly increased (37.6 2.70) in Group B (5 mg/kg) when compared with the control (32.4 2.30). AST decreased significantly in all the treatment groups (68 1.58, 87.4 403, and 89 1.58) when compared with the control (93.6 1.14). ALT decreased in all groups but was significant in Group C (7.5 mg/kg) 22.8 2.16 when compared with the control (30 2.12). Urea decreased significantly in all the groups (3.34 0.11, 3.78 0.50, and 3.36 0.28), creatinine decreased significantly in Group B (35.4 2.79) when compared to their controls (4.52 0.37 and 50.8 6.37), respectively. Na+ and K+ significantly decreased in Groups C and B, respectively; there was no significant difference in other groups and electrolytes. There was increased level of both packed cell volume and hemoglobin significantly. Histologically, there were no tissue alterations in all the treatment groups.
Conclusion: Complementary and alternative medicine is fast gaining popularity; this necessitates swift research on various dose ranges.

Key words: Hepactocyte, Podocyte, Complementary and Alternative Medicine


 
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How to Cite this Article
Pubmed Style

Onyije FM, Zenebo VC, Bankole JK, Digban kA, Avwioro GO. Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. J Interdiscipl Histopathol. 2016; 4(1): 17-22. doi:10.5455/jihp.20160321010001


Web Style

Onyije FM, Zenebo VC, Bankole JK, Digban kA, Avwioro GO. Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. http://www.jidhp.com/?mno=216872 [Access: January 23, 2018]. doi:10.5455/jihp.20160321010001


AMA (American Medical Association) Style

Onyije FM, Zenebo VC, Bankole JK, Digban kA, Avwioro GO. Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. J Interdiscipl Histopathol. 2016; 4(1): 17-22. doi:10.5455/jihp.20160321010001



Vancouver/ICMJE Style

Onyije FM, Zenebo VC, Bankole JK, Digban kA, Avwioro GO. Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. J Interdiscipl Histopathol. (2016), [cited January 23, 2018]; 4(1): 17-22. doi:10.5455/jihp.20160321010001



Harvard Style

Onyije, F. M., Zenebo, V. C., Bankole, J. K., Digban, k. A. & Avwioro, G. O. (2016) Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. J Interdiscipl Histopathol, 4 (1), 17-22. doi:10.5455/jihp.20160321010001



Turabian Style

Onyije, Felix M, Vivian C Zenebo, Julius K Bankole, kester A Digban, and Godwin O Avwioro. 2016. Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. Journal of Interdisciplinary Histopathology, 4 (1), 17-22. doi:10.5455/jihp.20160321010001



Chicago Style

Onyije, Felix M, Vivian C Zenebo, Julius K Bankole, kester A Digban, and Godwin O Avwioro. "Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf." Journal of Interdisciplinary Histopathology 4 (2016), 17-22. doi:10.5455/jihp.20160321010001



MLA (The Modern Language Association) Style

Onyije, Felix M, Vivian C Zenebo, Julius K Bankole, kester A Digban, and Godwin O Avwioro. "Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf." Journal of Interdisciplinary Histopathology 4.1 (2016), 17-22. Print. doi:10.5455/jihp.20160321010001



APA (American Psychological Association) Style

Onyije, F. M., Zenebo, V. C., Bankole, J. K., Digban, k. A. & Avwioro, G. O. (2016) Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration of Low Dose of Carica Papaya Leaf. Journal of Interdisciplinary Histopathology, 4 (1), 17-22. doi:10.5455/jihp.20160321010001





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