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Review Article Open Access


Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions

Sowmya Rao, Jagadish Rao, Jyothi B.M, Varsha V.K.

Abstract
Myofibroblasts are one of the most controversial cells in recent times. Ever since its first discovery, numerous discussions have been done on its illusive nature and functions. They are commonly considered as smooth muscle like fibroblasts. Their presence and distribution in normal and pathological conditions are still not clear since they are difficult to identify with the routine histological techniques. Recent studies have shown their ubiquitous presence in the body tissues hence suggesting their important role in both physiological functioning and pathological conditions. This review discusses briefly the cell in terms of its definition, possible precursors; mechanism involved in its modulation, most importantly how to differentiate it from its nearest counterparts such as fibroblasts and smooth muscle cells and finally its fundamental role in physiology and pathology.

Key words: Myofibroblasts, Transforming Growth Factor-β, Alpha-Smooth Muscle Actin, fibronexsus, wound healing


 
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Pubmed Style

Rao S, Rao J, B.M J, V.K V. Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. J Interdiscipl Histopathol. 2017; 5(1): 12-17. doi:10.5455/jihp.20160622013430


Web Style

Rao S, Rao J, B.M J, V.K V. Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. http://www.jidhp.com/?mno=229369 [Access: January 23, 2018]. doi:10.5455/jihp.20160622013430


AMA (American Medical Association) Style

Rao S, Rao J, B.M J, V.K V. Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. J Interdiscipl Histopathol. 2017; 5(1): 12-17. doi:10.5455/jihp.20160622013430



Vancouver/ICMJE Style

Rao S, Rao J, B.M J, V.K V. Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. J Interdiscipl Histopathol. (2017), [cited January 23, 2018]; 5(1): 12-17. doi:10.5455/jihp.20160622013430



Harvard Style

Rao, S., Rao, J., B.M, J. & V.K, V. (2017) Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. J Interdiscipl Histopathol, 5 (1), 12-17. doi:10.5455/jihp.20160622013430



Turabian Style

Rao, Sowmya, Jagadish Rao, Jyothi B.M, and Varsha V.K. 2017. Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. Journal of Interdisciplinary Histopathology, 5 (1), 12-17. doi:10.5455/jihp.20160622013430



Chicago Style

Rao, Sowmya, Jagadish Rao, Jyothi B.M, and Varsha V.K. "Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions." Journal of Interdisciplinary Histopathology 5 (2017), 12-17. doi:10.5455/jihp.20160622013430



MLA (The Modern Language Association) Style

Rao, Sowmya, Jagadish Rao, Jyothi B.M, and Varsha V.K. "Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions." Journal of Interdisciplinary Histopathology 5.1 (2017), 12-17. Print. doi:10.5455/jihp.20160622013430



APA (American Psychological Association) Style

Rao, S., Rao, J., B.M, J. & V.K, V. (2017) Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple Functions. Journal of Interdisciplinary Histopathology, 5 (1), 12-17. doi:10.5455/jihp.20160622013430





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