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Case Report Open Access


Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case

Michal Zamecnik.

Abstract
An unusual case of epithelioid hemangioendothelioma (EHE) with immunohistochemical positivity for cytokeratin (CK), alpha-smooth muscle actin, and calponin (CALP) is presented. The lesion occurred in a 43-year-old man in the right frontal region, with clinical suspicion for an epidermoid cyst. It was excised completely. Grossly, an 8 mm nodule was well circumscribed, soft, and it had gray cut surface. Histologically, typical features of EHE were seen, such angiocentric localization, epithelioid cytomorphology with mild atypia, myxohyaline stromal matrix, a few slit-like vascular channels, and isolated vacuolated cells. In addition, the stroma contained numerous spindle cells resembling myoblasts or myofibroblasts. They showed, besides scattered positivity for vascular markers, focal positivity for CALP and diffuse strong expression of alpha-smooth muscle actin and pancytokeratin AE1/AE3. This observation of numerous actin+/CK+cells is unusual. The lesion resembled other CK-positive vascular tumors and actin-positive myofibroblastic lesions, all of which has to be considered in differential diagnosis.

Key words: epithelioid haemangioendothelioma, epithelioid sarcoma-like/pseudomyogenic haemangioendothelioma, epithelioid haemangioma, cytokeratin, smooth muscle actin


 
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REFERENCES
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How to Cite this Article
Pubmed Style

Michal Zamecnik. Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. J Interdiscipl Histopathol. 2016; 4(3): 79-82. doi:10.5455/jihp.20160823075851


Web Style

Michal Zamecnik. Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. http://www.jidhp.com/?mno=231464 [Access: January 20, 2018]. doi:10.5455/jihp.20160823075851


AMA (American Medical Association) Style

Michal Zamecnik. Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. J Interdiscipl Histopathol. 2016; 4(3): 79-82. doi:10.5455/jihp.20160823075851



Vancouver/ICMJE Style

Michal Zamecnik. Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. J Interdiscipl Histopathol. (2016), [cited January 20, 2018]; 4(3): 79-82. doi:10.5455/jihp.20160823075851



Harvard Style

Michal Zamecnik (2016) Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. J Interdiscipl Histopathol, 4 (3), 79-82. doi:10.5455/jihp.20160823075851



Turabian Style

Michal Zamecnik. 2016. Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. Journal of Interdisciplinary Histopathology, 4 (3), 79-82. doi:10.5455/jihp.20160823075851



Chicago Style

Michal Zamecnik. "Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case." Journal of Interdisciplinary Histopathology 4 (2016), 79-82. doi:10.5455/jihp.20160823075851



MLA (The Modern Language Association) Style

Michal Zamecnik. "Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case." Journal of Interdisciplinary Histopathology 4.3 (2016), 79-82. Print. doi:10.5455/jihp.20160823075851



APA (American Psychological Association) Style

Michal Zamecnik (2016) Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case. Journal of Interdisciplinary Histopathology, 4 (3), 79-82. doi:10.5455/jihp.20160823075851





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