Journal of Interdisciplinary Histopathology



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Original Research Open Access


Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades

Dibyajyoti Boruah.

Abstract
Objective: The main objectives of this study were: to evaluate nuclear major axis(MAJX) and minor axis(MINX), nuclear area(NA), nuclear perimeter(NP), nuclear aspect ratio(NAR) and nuclear roundness(NR) with their variability using morphometric techniques in malignant and benign ovarian tumors and to correlate them with histological grades. Methods: Morphometric parameters were evaluated in 8 low grade(LG) and 22 high grade(HG) serous ovarian carcinoma; and 30 benign(BG) cases by digital image morphometric technique using histological sections. Results: The mean of the size related nuclear parameters: MAJX, MINX, NA, NP and their variability were significantly greater (p30.44m2, can be used to differentiate from benign with 100% efficiency. Conclusion: Morphometric parameters related to nuclear size and their variability were significantly larger in malignant cases than the benign, and showed strong positive correlation with the grades. Nuclear shapes of the malignant nuclei were rounder than the benign. Nuclear morphometry can be gainfully exploited in the diagnosis of ovarian carcinoma quantitatively.

Key words: serous ovarian tumor, nuclear parameters, morphometric analysis


 
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Pubmed Style

Dibyajyoti Boruah. Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. J Interdiscipl Histopathol. 2017; 5(3): 69-74. doi:10.5455/jihp.20170607073657



Web Style

Dibyajyoti Boruah. Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. www.scopemed.org/?mno=242170 [Access: August 24, 2017]. doi:10.5455/jihp.20170607073657



AMA (American Medical Association) Style

Dibyajyoti Boruah. Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. J Interdiscipl Histopathol. 2017; 5(3): 69-74. doi:10.5455/jihp.20170607073657



Vancouver/ICMJE Style

Dibyajyoti Boruah. Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. J Interdiscipl Histopathol. (2017), [cited August 24, 2017]; 5(3): 69-74. doi:10.5455/jihp.20170607073657



Harvard Style

Dibyajyoti Boruah (2017) Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. J Interdiscipl Histopathol, 5 (3), 69-74. doi:10.5455/jihp.20170607073657



Turabian Style

Dibyajyoti Boruah. 2017. Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. Journal of Interdisciplinary Histopathology, 5 (3), 69-74. doi:10.5455/jihp.20170607073657



Chicago Style

Dibyajyoti Boruah. "Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades." Journal of Interdisciplinary Histopathology 5 (2017), 69-74. doi:10.5455/jihp.20170607073657



MLA (The Modern Language Association) Style

Dibyajyoti Boruah. "Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades." Journal of Interdisciplinary Histopathology 5.3 (2017), 69-74. Print. doi:10.5455/jihp.20170607073657



APA (American Psychological Association) Style

Dibyajyoti Boruah (2017) Utility of nuclear morphometry in serous ovarian carcinoma and its correlation with grades. Journal of Interdisciplinary Histopathology, 5 (3), 69-74. doi:10.5455/jihp.20170607073657