Journal of Interdisciplinary Histopathology



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Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine

Bianca Ribeiro de Souza, Lucas Solla Mathias, Talita Iara Maximo de Souza, Isabel Cristina Cherici Camargo.

Abstract
Objective: Frequently, reproductive toxic substances such as androgenic anabolic steroids, alcohol and nicotine are used in association by adolescents and adults, in an indiscriminate manner. This study investigated the testicular and epididymal tissue of adult rats submitted to a recovery period after treatment with anabolic steroid, alcohol and /or nicotine. Materials and Methods: The animals (n=42) were divided into three control groups simulating the drugs administration routes (CI: distilled water, oral; CII: saline solution, subcutaneous; CIII: water and saline solution) and groups treated with a testosterone esters mixture (T: 7.5 mg/kg body weight - b.w., subcutaneous), alcohol (AL: 3.5 g/kg b.w. of ethanol 25%, oral), nicotine (N: 2.0 mg/kg b.w., subcutaneous), and co-administration of these three substances (T/AL/N). After 15 consecutive days of treatment (once a day), the animals were kept for 30 days in recovery. At the end of this period, the testes and epididymides were collected, weighed and processed for histological and morphometric analysis by light microscope. Results: All groups treated with toxic substances presented histopathological changes in testes and epididymis after the recovery period. There was a significant decrease (p

Key words: Testosterone; Ethanol; Nicotine; Male Reproduction; Histopathology


 
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Pubmed Style

Souza BRd, Mathias LS, Souza TIMd, Camargo ICC. Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. J Interdiscipl Histopathol. 2017; 5(3): 92-98. doi:10.5455/jihp.20170124093401



Web Style

Souza BRd, Mathias LS, Souza TIMd, Camargo ICC. Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. www.scopemed.org/?mno=246963 [Access: August 24, 2017]. doi:10.5455/jihp.20170124093401



AMA (American Medical Association) Style

Souza BRd, Mathias LS, Souza TIMd, Camargo ICC. Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. J Interdiscipl Histopathol. 2017; 5(3): 92-98. doi:10.5455/jihp.20170124093401



Vancouver/ICMJE Style

Souza BRd, Mathias LS, Souza TIMd, Camargo ICC. Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. J Interdiscipl Histopathol. (2017), [cited August 24, 2017]; 5(3): 92-98. doi:10.5455/jihp.20170124093401



Harvard Style

Souza, B. R. d., Mathias, L. S., Souza, T. I. M. d. & Camargo, I. C. C. (2017) Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. J Interdiscipl Histopathol, 5 (3), 92-98. doi:10.5455/jihp.20170124093401



Turabian Style

Souza, Bianca Ribeiro de, Lucas Solla Mathias, Talita Iara Maximo de Souza, and Isabel Cristina Cherici Camargo. 2017. Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. Journal of Interdisciplinary Histopathology, 5 (3), 92-98. doi:10.5455/jihp.20170124093401



Chicago Style

Souza, Bianca Ribeiro de, Lucas Solla Mathias, Talita Iara Maximo de Souza, and Isabel Cristina Cherici Camargo. "Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine." Journal of Interdisciplinary Histopathology 5 (2017), 92-98. doi:10.5455/jihp.20170124093401



MLA (The Modern Language Association) Style

Souza, Bianca Ribeiro de, Lucas Solla Mathias, Talita Iara Maximo de Souza, and Isabel Cristina Cherici Camargo. "Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine." Journal of Interdisciplinary Histopathology 5.3 (2017), 92-98. Print. doi:10.5455/jihp.20170124093401



APA (American Psychological Association) Style

Souza, B. R. d., Mathias, L. S., Souza, T. I. M. d. & Camargo, I. C. C. (2017) Histopathological and Morphometric Evaluation in the Testis and Epididymis of Adult Rats Submitted To A Recovery Period after Treatment with Anabolic Steroid, Alcohol and/or Nicotine. Journal of Interdisciplinary Histopathology, 5 (3), 92-98. doi:10.5455/jihp.20170124093401