Journal of Interdisciplinary Histopathology



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Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats

Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob.

Abstract
Fluorides have been a cause of concern for scientists and environmentalists for the long because of their harmful effects on the human and animal life but the problem was highlighted during the twentieth century because of great increase in the human population and industrialization. Since fluorides accumulate in calcified and hard tissues of the body such as bone and teeth and can be detected easily in these tissues, so most of the previous studies focused on the effects of fluorides on these tissues. However, during the past decade researchers all over the world have felt that there is a need to study the effects of fluorides on various other tissues of the body including CNS as fluoride intake for prolonged period is known to cause abnormal behavioural pattern, grave implications for Alzheimer’s Disease, Dementia, Attention deficit disorder and reduced I.Q in children as the fluorides are known to cross blood brain barrier. Hence the present study has thrown light on the involvement of brain in chronic fluoride toxicity. The target organ of studied was cerebrum. In the Study, albino rats were exposed to 30 or 100 ppm fluoride (asNaF) in drinking water for 3 months. Rats exposed to 30 ppm fluoride did not show any notable alterations in brain histology, whereas rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in lhe motor cortex.Changes included decrease in size and number of neurons in all the regions, signs of chromatolysis and gliosis in the motor cortex. These histological changes suggest a toxic effect of high-fluoride intake & on chronic use.

Key words: Albino rats, histology, Cerebrum, Fluoride, Intoxication


 
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REFERENCES
1. Marrier, JR. "The ecological aspects of fluoride". Fluoride 1972; 5:92-97.


2. Markiewicz, J. Toxicological problems of inorganic fluorine compounds. Folia Medica Cracoviensia 1981; 23:323-327.

[
Pubmed]   

3. Waldbott, JL. Chronic fluorine intoxication from drinking water at 1 ppm concentration. A case report. Int Arch Allergy 1955;7:70

http://dx.doi.org/10.1159/000228212

[
Pubmed]   

4. AWB and JC. Neurotoxicity of fluoride. Fluoride 1996; 29: 57-58.


5. Geeraerts F., Gijs G., Finne E., Crokaert R., Kinetics of fluoride Penetrate in liver and brain. Fluoride 1986; 19: 108-112.


6. Mullenix PJ, Denberlen PK, Schunior A, Kernan WJ, Neurotoxicity of sodium fluoride in rats. Neurotoxicology Teratology 1995; 17: 169-177.

http://dx.doi.org/10.1016/0892-0362(94)00070-T


7. Varner JA, Huie C, Horvath W, Jensen KF, Isaacson RL. Chronic aluminium fluoride administration II selected histological observations. Research Neuroscience Communication 1993; 13: 99-104.


8. Shashi A. Studies on alterations in brain lipid metanolosm following experimental fluorosis. Fluoride; 1992; 25: 77-84.


9. Guan ZZ, Wang YN, Xiao KQ, Dia DY, Chen YH, Liu JL, Sindelar P, Dallner G, Chronic fluorosis on membrane fluorides in rats brain. Neurotoxicology Teratology 1988; 20: 537-542.

http://dx.doi.org/10.1016/S0892-0362(97)00136-0


10. Mattson J.L., Albee R.R., Eisenbrandt DL, Chang LW, Subchronic neurotoxicity of the structural fumigant sulfuryl fluoride. Neurotoxicology Teratology 1988; 10: 127-133.

http://dx.doi.org/10.1016/0892-0362(88)90076-1


11. Liu, WX. Experimental study of behaviour and cerebral morphology of rat pups generated by fluorotic female rat. Chung-hua Ping Li Hsueh Tsa Chih 1989; 18: 290-292.

[
Pubmed]   

12. Yu Y, Yang W, Dong Z, et al. Changes in neurotransmitters and their receptors in human foetal brain from an endemic fluorosis area. Chung Hua Liu Hsing Ping Hsueh Tsa Chih 1996; 15: 257-259.


13. Zhang A, Zhu D. Effect of fluoride on the human fetus. Chinese Journal of Endemic Prevention and Treatment 1998; 13: 156-158.


14. Shi J, Dai G, et al. A study of the effects of fluoride on the human fetus in an endemic fluorosis area. Chung Hua Liu Hsing Ping Hsueh Tsa Chih 1990; 9: 10-12.


15. Chen Z, Liu W, Su G. A study of the effects of fluoride on foetal tissue. Chinese Journal of Endemiology, 1990;9: 345-346.


16. Li XS, Zhi JL, Gao RO. Effect of fluoride exposure on intelligence in children. Fluoride 1995; 28: 189-192.


17. Zhao LB, Liang GH, Zhang DN, Wu XR. Effect of a high fluoride water supply on children's intelligence. Fluoride 1996; 29: 190-192.


18. Ren DL, Liu Y, An Q. An investigation of intelligence development of children aged 8-14 years in high fluoride and low iodine areas. Chinese Journal of Control of Endemic Diseases 19894:251-254.


19. Roholm K. Fluorine intoxication: a clinical-hygienic study with a review of the literature and some experimental investigations. London: HK Lewis; 1937, p. 28.


20. Philips PH, Lamb AR. Histology of certain organs and teeth in chronic toxicosis due to fluorine. Arch Pathol 1934; 17:169.


21. Lindman, GP. Recovery of the rat kidney on fluorosis. Arch Pathol 1956; 67:30.


22. Messer HH, Wong K, Wagner M, Singer L, Armstrong WD. Effects of reduced fluoride intake by mice on hematocrit values. Nature New Biology 1972; 240:218-219.

[
Pubmed]   

23. Singh A, Jolly SS. Endemic fluorosis with particular reference to fluorotic radiculomyelopathy. Quart J Med 1961; 30:357-372.

[
Pubmed]   

24. Reddy OD, Sharda D. Endemic fluorosis. J. Ind. Med. Assoc. 1969; 53:275-281.

[
Pubmed]   

25. Isaacson R., Rat studies link brain cell damage with aluminum & fluoride in State Univ. of New York, Binghampton, N. WY,all Street Journal Article By Marilyn Chase, Oct. 28 1992, P.B.-6.


26. Varner J.A., Jensen KF, Horvath W, Isaacson RL. Chronic administration of aluminum-fluoride and sodium-fluoride to rats in drinking water: alteration neuronal and cerebrovascular integrity. Brain research 1998; 784:284-298.

http://dx.doi.org/10.1016/S0006-8993(97)01336-X


27. Kaur T, Bijarnia RK, Nehru B. Effect of concurrent exposure of fluoride & aluminum on rat brain. Drug Chem Toxicol 2009; 32(3): 215-221.

http://dx.doi.org/10.1080/01480540902862251

[
Pubmed]   

28. Nwaopara AO, Anibeze CIP, Akpuaka FC. Histological signs of neurodegeneration in cerebrum fed with diet containing Yaji: The complex Nigerian Suya meat sauce. Asian Journal of Medical Sciences 2010; 2: 16-21.


How to Cite this Article
Pubmed Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscipl Histopathol. 2012; 1(1): 30-34. doi:10.5455/jihp.20121105123701



Web Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. www.scopemed.org/?mno=25280 [Access: June 28, 2017]. doi:10.5455/jihp.20121105123701



AMA (American Medical Association) Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscipl Histopathol. 2012; 1(1): 30-34. doi:10.5455/jihp.20121105123701



Vancouver/ICMJE Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscipl Histopathol. (2012), [cited June 28, 2017]; 1(1): 30-34. doi:10.5455/jihp.20121105123701



Harvard Style

Hamid, S., Kawoosa, Z., Hamid, S., Mir, M., Hafiz, A., Jan, I. & Yaqoob, . (2012) Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscipl Histopathol, 1 (1), 30-34. doi:10.5455/jihp.20121105123701



Turabian Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. 2012. Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. Journal of Interdisciplinary Histopathology, 1 (1), 30-34. doi:10.5455/jihp.20121105123701



Chicago Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. "Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats." Journal of Interdisciplinary Histopathology 1 (2012), 30-34. doi:10.5455/jihp.20121105123701



MLA (The Modern Language Association) Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. "Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats." Journal of Interdisciplinary Histopathology 1.1 (2012), 30-34. Print. doi:10.5455/jihp.20121105123701



APA (American Psychological Association) Style

Hamid, S., Kawoosa, Z., Hamid, S., Mir, M., Hafiz, A., Jan, I. & Yaqoob, . (2012) Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. Journal of Interdisciplinary Histopathology, 1 (1), 30-34. doi:10.5455/jihp.20121105123701