Journal of Interdisciplinary Histopathology



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Case Report Open Access


Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report

Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan.

Abstract
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as “double hit” lymphomas (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, and a spectrum of pathological features overlapping with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Primary renal lymphoma (PRL) by definition is a renal lymphoma without evidence of systemic involvement. PRL is extremely rare with less than 100 cases of both Hodgkin disease and non-Hodgkin lymphoma reported in literature. Double hit lymphomas have extremely poor prognosis, and high resistance to intensive chemotherapy, including high-dose chemotherapy. We describe a very rare case of DHL arising in kidney as PRL in whom concurrent IGH-BCL2 and MYC rearrangements were detected.

Key words: Primary renal lymphoma, double hit lymphoma


 
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How to Cite this Article
Pubmed Style

Mehta V, Ellimottil C, Speiser J, Velankar M, Barkan GA. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscipl Histopathol. 2013; 1(2): 93-97. doi:10.5455/jihp.20130121075815



Web Style

Mehta V, Ellimottil C, Speiser J, Velankar M, Barkan GA. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. www.scopemed.org/?mno=31474 [Access: August 24, 2017]. doi:10.5455/jihp.20130121075815



AMA (American Medical Association) Style

Mehta V, Ellimottil C, Speiser J, Velankar M, Barkan GA. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscipl Histopathol. 2013; 1(2): 93-97. doi:10.5455/jihp.20130121075815



Vancouver/ICMJE Style

Mehta V, Ellimottil C, Speiser J, Velankar M, Barkan GA. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscipl Histopathol. (2013), [cited August 24, 2017]; 1(2): 93-97. doi:10.5455/jihp.20130121075815



Harvard Style

Mehta, V., Ellimottil, C., Speiser, J., Velankar, M. & Barkan, G. A. (2013) Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. J Interdiscipl Histopathol, 1 (2), 93-97. doi:10.5455/jihp.20130121075815



Turabian Style

Mehta, Vikas, Chad Ellimottil, Jodi Speiser, Milind Velankar, and Guliz A Barkan. 2013. Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (2), 93-97. doi:10.5455/jihp.20130121075815



Chicago Style

Mehta, Vikas, Chad Ellimottil, Jodi Speiser, Milind Velankar, and Guliz A Barkan. "Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report." Journal of Interdisciplinary Histopathology 1 (2013), 93-97. doi:10.5455/jihp.20130121075815



MLA (The Modern Language Association) Style

Mehta, Vikas, Chad Ellimottil, Jodi Speiser, Milind Velankar, and Guliz A Barkan. "Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report." Journal of Interdisciplinary Histopathology 1.2 (2013), 93-97. Print. doi:10.5455/jihp.20130121075815



APA (American Psychological Association) Style

Mehta, V., Ellimottil, C., Speiser, J., Velankar, M. & Barkan, G. A. (2013) Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report. Journal of Interdisciplinary Histopathology, 1 (2), 93-97. doi:10.5455/jihp.20130121075815