Journal of Interdisciplinary Histopathology



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Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry

Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal.

Abstract
OBJECTIVES: Angiogenesis plays a key role in tumor growth and metastasis. The analysis of tumor vascularization by microvessel density (MVD) and its prognostic significance has been evaluated in many tumors including ovary. However, very few studies have tried to evaluate the characteristics of these vessels. This study aims to quantitatively assess the characteristics of tumor vessels with the aid of immunohistochemistry and thus, establish its role in difference in biological behavior of benign and malignant surface epithelial ovarian tumors.
METHODS: We examined 42 cases of surface epithelial ovarian tumors and divided them in two groups (14 malignant and 28 benign tumors). Both study groups were compared for smooth muscle and endothelial cells in tumor vessels using monoclonal antibodies against smooth muscle actin (SMA) and CD34 (endothelial cell marker) respectively. MVD, SMA expression index and CD34 intensity index was calculated in both groups.
RESULTS: The malignant surface epithelial ovarian tumors showed higher MVD (34.48±12.87) as compared to benign ovarian tumors (16.49±6.17) (p

Key words: Ovarian, Angiogenesis, MVD, CD34 intensity index, SMA expression index


 
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How to Cite this Article
Pubmed Style

Sehgal S, Goyal P, Agarwal R, Singh S, Kumar A, Gupta R, Kumar V, Agrawal D. Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. J Interdiscipl Histopathol. 2013; 1(3): 145-152. doi:10.5455/jihp.20130204114930



Web Style

Sehgal S, Goyal P, Agarwal R, Singh S, Kumar A, Gupta R, Kumar V, Agrawal D. Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. www.scopemed.org/?mno=31890 [Access: June 28, 2017]. doi:10.5455/jihp.20130204114930



AMA (American Medical Association) Style

Sehgal S, Goyal P, Agarwal R, Singh S, Kumar A, Gupta R, Kumar V, Agrawal D. Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. J Interdiscipl Histopathol. 2013; 1(3): 145-152. doi:10.5455/jihp.20130204114930



Vancouver/ICMJE Style

Sehgal S, Goyal P, Agarwal R, Singh S, Kumar A, Gupta R, Kumar V, Agrawal D. Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. J Interdiscipl Histopathol. (2013), [cited June 28, 2017]; 1(3): 145-152. doi:10.5455/jihp.20130204114930



Harvard Style

Sehgal, S., Goyal, P., Agarwal, R., Singh, S., Kumar, A., Gupta, R., Kumar, V. & Agrawal, D. (2013) Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. J Interdiscipl Histopathol, 1 (3), 145-152. doi:10.5455/jihp.20130204114930



Turabian Style

Sehgal, Shelly, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, and Dipti Agrawal. 2013. Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. Journal of Interdisciplinary Histopathology, 1 (3), 145-152. doi:10.5455/jihp.20130204114930



Chicago Style

Sehgal, Shelly, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, and Dipti Agrawal. "Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry." Journal of Interdisciplinary Histopathology 1 (2013), 145-152. doi:10.5455/jihp.20130204114930



MLA (The Modern Language Association) Style

Sehgal, Shelly, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, and Dipti Agrawal. "Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry." Journal of Interdisciplinary Histopathology 1.3 (2013), 145-152. Print. doi:10.5455/jihp.20130204114930



APA (American Psychological Association) Style

Sehgal, S., Goyal, P., Agarwal, R., Singh, S., Kumar, A., Gupta, R., Kumar, V. & Agrawal, D. (2013) Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry. Journal of Interdisciplinary Histopathology, 1 (3), 145-152. doi:10.5455/jihp.20130204114930