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Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters

Fatma Emaetig, Khaled El Gehani, Ibtesam El Hasadi, Adam Elzagheid, Abdelbaset Buhmeida.

Abstract
Objective: The aim of the current study is to cast further light on the issues related to prognostication of renal cell carcinoma (RCC), assessing the expression of survivin in a subset of primary RCC and determine its relation to different clinicopathological features and disease free survival.
Patients and Methods: The present series consisted of tissue samples obtained from 37 Libyan patients with stage I, II, III, or IV RCC. Survivin expression in these tumors was assessed by immunohistochemistry using an automated staining system. Different grading systems were tested for expression of survivin.
Results: Expression of survivin was significantly associated with venous invasion (tumor thrombus) (p= 0.042), larger tumor size (p= 0.051), higher primary T classification (p= 0.013), advanced tumor stage (p= 0.033), and borderline association (p= 0.068) with tumor location. In univariate (Kaplan-Meier) survival analysis, survivin expression showed a borderline association (p= 0.089) with disease-free survival (DFS). However, there was no significant correlation between survivin expression and gender, age, histological grade, distance metastasis, lymph node involvement, perinephric fat and capsular invasion, status at end point and recurrence.
Conclusion: Survivin expression in RCC may identify patients at risk of a more aggressive disease and a worse prognosis, further investigations, on a larger and more heterogeneous population, should be carried out to validate and extend our results.

Key words: Key Words: Survivin, Renal cell carcinoma, immunohistochemistry, apoptosis, prognosis.


 
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How to Cite this Article
Pubmed Style

Emaetig F, Gehani KE, Hasadi IE, Elzagheid A, Buhmeida A. Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. J Interdiscipl Histopathol. 2013; 1(4): 184-194. doi:10.5455/jihp.20130324114215


Web Style

Emaetig F, Gehani KE, Hasadi IE, Elzagheid A, Buhmeida A. Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. http://www.jidhp.com/?mno=34826 [Access: January 23, 2018]. doi:10.5455/jihp.20130324114215


AMA (American Medical Association) Style

Emaetig F, Gehani KE, Hasadi IE, Elzagheid A, Buhmeida A. Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. J Interdiscipl Histopathol. 2013; 1(4): 184-194. doi:10.5455/jihp.20130324114215



Vancouver/ICMJE Style

Emaetig F, Gehani KE, Hasadi IE, Elzagheid A, Buhmeida A. Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. J Interdiscipl Histopathol. (2013), [cited January 23, 2018]; 1(4): 184-194. doi:10.5455/jihp.20130324114215



Harvard Style

Emaetig, F., Gehani, K. E., Hasadi, I. E., Elzagheid, A. & Buhmeida, A. (2013) Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. J Interdiscipl Histopathol, 1 (4), 184-194. doi:10.5455/jihp.20130324114215



Turabian Style

Emaetig, Fatma, Khaled El Gehani, Ibtesam El Hasadi, Adam Elzagheid, and Abdelbaset Buhmeida. 2013. Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. Journal of Interdisciplinary Histopathology, 1 (4), 184-194. doi:10.5455/jihp.20130324114215



Chicago Style

Emaetig, Fatma, Khaled El Gehani, Ibtesam El Hasadi, Adam Elzagheid, and Abdelbaset Buhmeida. "Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters." Journal of Interdisciplinary Histopathology 1 (2013), 184-194. doi:10.5455/jihp.20130324114215



MLA (The Modern Language Association) Style

Emaetig, Fatma, Khaled El Gehani, Ibtesam El Hasadi, Adam Elzagheid, and Abdelbaset Buhmeida. "Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters." Journal of Interdisciplinary Histopathology 1.4 (2013), 184-194. Print. doi:10.5455/jihp.20130324114215



APA (American Psychological Association) Style

Emaetig, F., Gehani, K. E., Hasadi, I. E., Elzagheid, A. & Buhmeida, A. (2013) Survivin Expression in Renal Cell Carcinoma and Its Correlation with Clinicopathological Parameters. Journal of Interdisciplinary Histopathology, 1 (4), 184-194. doi:10.5455/jihp.20130324114215





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