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A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.

Nicole Dalton Wheeler, Marian Rollins-Raval, Steven H. Swerdlow, Swati Modi, Kimberly Liang, Robyn T. Domsic, Kathleen R. Sheridan.

Abstract
Human cases of brucellosis are rare in the United States and difficult to diagnose. We report a case of a young female who underwent a diagnostic investigation of fever of unknown origin, which included a lymph node biopsy. The biopsy was consistent with Kikuchi’s Disease, or histiocytic necrotizing lymphadenitis, an entity where the major differential diagnosis is systemic lupus erythematosus. Interestingly, serologic studies supported the diagnosis of brucellosis. Brucellosis has rarely been associated with histiocytic necrotizing lymphadenitis. This association has never been reported in the United States, thus suggesting that brucellosis should be considered in the differential for histiocytic necrotizing lymphadenitis, along with lupus-like autoimmune disease. As the prognosis and treatment of histiocytic necrotizing lymphadenitis, brucellosis, and systemic lupus erythematosus are distinct, it is important to differentiate these entities.

Key words: Brucellosis, Kikuchi’s disease, histiocytic necrotizing lymphadenitis, systemic lupus erythematosus


 
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How to Cite this Article
Pubmed Style

Wheeler ND, Rollins-Raval M, Swerdlow SH, Modi S, Liang K, Domsic RT, Sheridan KR. A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. J Interdiscipl Histopathol. 2013; 1(5): 274-279. doi:10.5455/jihp.20130722113848


Web Style

Wheeler ND, Rollins-Raval M, Swerdlow SH, Modi S, Liang K, Domsic RT, Sheridan KR. A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. http://www.jidhp.com/?mno=39767 [Access: January 23, 2018]. doi:10.5455/jihp.20130722113848


AMA (American Medical Association) Style

Wheeler ND, Rollins-Raval M, Swerdlow SH, Modi S, Liang K, Domsic RT, Sheridan KR. A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. J Interdiscipl Histopathol. 2013; 1(5): 274-279. doi:10.5455/jihp.20130722113848



Vancouver/ICMJE Style

Wheeler ND, Rollins-Raval M, Swerdlow SH, Modi S, Liang K, Domsic RT, Sheridan KR. A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. J Interdiscipl Histopathol. (2013), [cited January 23, 2018]; 1(5): 274-279. doi:10.5455/jihp.20130722113848



Harvard Style

Wheeler, N. D., Rollins-Raval, M., Swerdlow, S. H., Modi, S., Liang, K., Domsic, R. T. & Sheridan, K. R. (2013) A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. J Interdiscipl Histopathol, 1 (5), 274-279. doi:10.5455/jihp.20130722113848



Turabian Style

Wheeler, Nicole Dalton, Marian Rollins-Raval, Steven H. Swerdlow, Swati Modi, Kimberly Liang, Robyn T. Domsic, and Kathleen R. Sheridan. 2013. A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. Journal of Interdisciplinary Histopathology, 1 (5), 274-279. doi:10.5455/jihp.20130722113848



Chicago Style

Wheeler, Nicole Dalton, Marian Rollins-Raval, Steven H. Swerdlow, Swati Modi, Kimberly Liang, Robyn T. Domsic, and Kathleen R. Sheridan. "A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.." Journal of Interdisciplinary Histopathology 1 (2013), 274-279. doi:10.5455/jihp.20130722113848



MLA (The Modern Language Association) Style

Wheeler, Nicole Dalton, Marian Rollins-Raval, Steven H. Swerdlow, Swati Modi, Kimberly Liang, Robyn T. Domsic, and Kathleen R. Sheridan. "A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.." Journal of Interdisciplinary Histopathology 1.5 (2013), 274-279. Print. doi:10.5455/jihp.20130722113848



APA (American Psychological Association) Style

Wheeler, N. D., Rollins-Raval, M., Swerdlow, S. H., Modi, S., Liang, K., Domsic, R. T. & Sheridan, K. R. (2013) A Case of Brucellosis Associated with Histiocytic Necrotizing Lymphadenitis: A Diagnostic Pitfall.. Journal of Interdisciplinary Histopathology, 1 (5), 274-279. doi:10.5455/jihp.20130722113848





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