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IgG4-related Disease of the Genitourinary Tract

Mukul K. Divatia, Jae Y Ro.

Abstract
IgG4-related disease (IgG4-RD) is a recently established albeit well recognized fibro-inflammatory condition with distinctive features including a characteristic histopathological appearance; a propensity to develop tumefactive lesions in multiple body sites; and oft elevated serum IgG4 levels. The consensus statement on IgG-4 RD equips practicing pathologists with a set of working guidelines for the diagnosis of pathologic lesions identified in a host of different organ system affected with this disease. The diagnosis of IgG4-RD requires the combined presence of the characteristic histopathological appearance and increased numbers of IgG4-positive plasma cells. The essential histopathological features include a dense lymphoplasmacytic infiltrate, a storiform pattern of fibrosis, and obliterative phlebitis. Tissue IgG4-positive plasma cell counts and IgG4: IgG ratios are significant ancillary aids in establishing the diagnosis. The spectrum of IgG4-RD continues to expand and involve multiple body sites. The genitourinary system comprising of the kidneys, ureters, urinary bladder, urethra, prostate gland, testes and penis is one of the multiple organ systems to be affected by IgG4-RD. This review describes the clinical and histopathologic patterns of involvement of the genitourinary system by IgG4-RD, in association with serologic and radiological features.

Key words: IgG4-related disease; plasma cells; storiform fibrosis; obliterative thrombophlebitis; genitourinary tract


 
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REFERENCES
1. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012; 25:1181-92.

http://dx.doi.org/10.1038/modpathol.2012.72

[Pubmed]   

2. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001;344:732–738.

http://dx.doi.org/10.1056/NEJM200103083441005

[
Pubmed]   

3. Divatia M, Kim SA, Ro JY. IgG4-related sclerosing disease, an emerging entity: a review of a multi-system disease. Yonsei Med J 2012;53:15-34.

http://dx.doi.org/10.3349/ymj.2012.53.1.15

[
Pubmed]    [PMC Free Fulltext]   

4. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012;366:539-551.

http://dx.doi.org/10.1056/NEJMra1104650

[
Pubmed]   

5. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D; Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 2012;22:1-14.

http://dx.doi.org/10.1007/s10165-011-0508-6

[
Pubmed]    [PMC Free Fulltext]   

6. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012;22:21–30.

http://dx.doi.org/10.1007/s10165-011-0571-z

[
Pubmed]   

7. Zen Y, Nakanuma Y. IgG4-related disease: a cross sectional study of 114 cases. Am J Surg Pathol 2010;34: 1812-1819.

http://dx.doi.org/10.1097/PAS.0b013e3181f7266b

[
Pubmed]   

8. Deshpande V, Gupta R, Sainani N, Sahani DV, Virk R, Ferrone C, Khosroshahi A, Stone JH, Lauwers GY. Subclassification of Autoimmune pancreatitis: a histologic classification with clinical significance. Am J Surg Pathol 2011;35:26-35.

http://dx.doi.org/10.1097/PAS.0b013e3182027717

[
Pubmed]   

9. Zen Y, Inoue D, Kitao A, Onodera M, Abo H, Miyayama S, Gabata T, Matsui O, Nakanuma Y.IgG4-related lung and pleural disease: a clinicopathologic study of 21 cases. Am J Surg Pathol 2009;33:1886–1893.

http://dx.doi.org/10.1097/PAS.0b013e3181bd535b

[
Pubmed]   

10. Cheuk W, Yuen HK, Chu SY, Chiu EK, Lam LK, Chan JK. Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol 2008; 32:671–681.

http://dx.doi.org/10.1097/PAS.0b013e318157c068

[
Pubmed]   

11. Cheuk W, Yuen HK, Chan JK. Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? Am J Surg Pathol 2007;31:643-645.

http://dx.doi.org/10.1097/01.pas.0000213445.08902.11

[
Pubmed]   

12. Sah RP, Chari ST. Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis. Curr Opin Rheumatol 2011;23:108-113.

http://dx.doi.org/10.1097/BOR.0b013e3283413469

[
Pubmed]   

13. Dhall D, Suriawinata AA, Tang LH, Shia J, Klimstra DS. Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis. Hum Pathol 2010;41:643-652.

http://dx.doi.org/10.1016/j.humpath.2009.10.019

[
Pubmed]   

14. Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, Okamoto A, Egawa N, Nakajima H. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol 2003;38:982-984.

http://dx.doi.org/10.1007/s00535-003-1175-y

[
Pubmed]   

15. Chari ST. Diagnosis of autoimmune pancreatitis using its five cardinal features: introducing the Mayo Clinic's HISORt criteria. J Gastroenterol 2007;42(Suppl 18): 39-41.

http://dx.doi.org/10.1007/s00535-007-2046-8

[
Pubmed]   

16. Cheuk W, Chan JK. IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol 2010;17:303-332.

http://dx.doi.org/10.1097/PAP.0b013e3181ee63ce

[
Pubmed]   

17. Sato Y, Notohara K, Kojima M, Takata K, Masaki Y, Yoshino T.IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 2010;60:247-258.

http://dx.doi.org/10.1111/j.1440-1827.2010.02524.x

[
Pubmed]   

18. Kitagawa S, Zen Y, Harada K, Sasaki M, Sato Y, Minato H, Watanabe K, Kurumaya H, Katayanagi K, Masuda S, Niwa H, Tsuneyama K, Saito K, Haratake J, Takagawa K, Nakanuma Y. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner's tumor). Am J Surg Pathol 2005;29:783-791.

http://dx.doi.org/10.1097/01.pas.0000164031.59940.fc

[
Pubmed]   

19. Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuchi K, Fujihara M, Kuraoka K, Nakai T, Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T. Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease. Mod Pathol 2009;22:589-599.

http://dx.doi.org/10.1038/modpathol.2009.17

[
Pubmed]   

20. Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, Cheuk W, Cornell L, Castillo CF, Ferry JA, Forcione D, Klöppel G, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Masaki Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani D, Sato Y, Smyrk T, Stone JR, Takahira M, Umehara H, Webster G, Yamamoto M, Yi E, Yoshino T, Zamboni G, Zen Y, Chari S. IgG4-related disease: Recommendations for the nomenclature of this condition and its individual organ system manifestations. Arthritis Rheum. 2012; 64:3061-3067.

http://dx.doi.org/10.1002/art.34593

[
Pubmed]   

21. Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, Yamanaka N, Inoue D, Yamamoto M, Takahashi H, Nomura H, Taguchi T, Umehara H, Makino H, Saito T.Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol 2011; 25: 810-819.


22. Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, Bhalodia A, Sohani AR, Zhang L, Chari S, Sethi S, Fidler ME, Cornell LD. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol 2011; 22: 1343-1352.

http://dx.doi.org/10.1681/ASN.2011010062

[
Pubmed]    [PMC Free Fulltext]   

23. Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, Yamamoto M, Takahashi H, Matsui S, Nakada S, Origuchi T, Hirabayashi A, Homma N, Tsubata Y, Takata T, Wada Y, Saito A, Fukase S, Ishioka K, Miyazaki K, Masaki Y, Umehara H, Sugai S, Narita I. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int 2010; 78:1016-1023.

http://dx.doi.org/10.1038/ki.2010.271

[
Pubmed]   

24. Cornell L. IgG4-related kidney disease. Semin Diagn Pathol 2012; 29: 245-250.

http://dx.doi.org/10.1053/j.semdp.2012.07.004

[
Pubmed]   

25. Nishi S, Imai N, Yoshida K, Ito Y, Saeki T. Clinicopathological findings of immunoglobulin G4-related kidney disease. Clin Exp Nephrol 2011; 15: 810-819.

http://dx.doi.org/10.1007/s10157-011-0526-x

[
Pubmed]   

26. Saeki T, Imai N, Ito T, Yamazaki H, Nishi S. Membranous nephropathy associated with IgG4-related systemic disease and without autoimmune pancreatitis. Clin Nephrol 2009; 71: 173-178.

http://dx.doi.org/10.5414/CNP71173

[
Pubmed]   

27. Cornell LD, Chicano SL, Deshpande V, Collins AB, Selig MK, Lauwers GY, Barisoni L, Colvin RB. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol 2007; 31:1586-1597.

http://dx.doi.org/10.1097/PAS.0b013e318059b87c

[
Pubmed]   

28. Alexander MP, Larsen CP, Gibson IW, Nasr SH, Sethi S, Fidler ME, Raissian Y, Takahashi N, Chari S, Smyrk TC, Cornell LD. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int 2013;83:455-462.

http://dx.doi.org/10.1038/ki.2012.382

[
Pubmed]   

29. Yoshita K, Kawano M, Mizushima I, Hara S, Ito Y, Imai N, Ueno M, Nishi S, Nomura H, Narita I, Saeki T. Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis: distinction from non-IgG4-related tubulointerstitial nephritis. Nephrol Dial Transplant 2012; 27: 2755-2761.

http://dx.doi.org/10.1093/ndt/gfr761

[
Pubmed]   

30. Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M; Japanese study group on IgG4-related nephropathy. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol 2011; 43: 536-549.

http://dx.doi.org/10.1016/j.humpath.2011.06.002

[
Pubmed]   

31. Kawano M, Mizushima I, Yamaguchi Y, Imai N, Nakashima H, Nishi S, Hisano S, Yamanaka N, Yamamoto M, Takahashi H, Umehara H, Saito T, Saeki T. Immunohistochemical characteristics of IgG4-related tubulointerstitial nephritis: detailed analysis of 20 Japanese cases. Int J Rheumatol 2012; 2012: 609795.

http://dx.doi.org/10.1155/2012/609795

[
Pubmed]    [PMC Free Fulltext]   

32. Houghton DC, Troxell ML. An abundance of IgG4+ plasma cells is not specific for IgG4-related tubulointerstitial nephritis. Mod Pathol 2011; 24:1480-1487.

http://dx.doi.org/10.1038/modpathol.2011.101

[
Pubmed]   

33. Chang SY, Keogh K, Lewis JE, Ryu JH, Yi ES. Increased IgG4-positive plasma cells in granulomatosis with polyangiitis: A diagnostic pitfall of IgG4- related disease. Int J Rheumatol 2012; 2012:121702.

http://dx.doi.org/10.1155/2012/121702

[
Pubmed]    [PMC Free Fulltext]   

34. Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E, Marasà M, Beck LH Jr, Salant DJ, Benigni A, D'Agati V, Remuzzi G.. Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis 2011; 58: 272-275.

http://dx.doi.org/10.1053/j.ajkd.2011.05.002

[
Pubmed]   

35. Morimoto J, Hasegawa Y, Fukushima H, Uesugi N, Hisano S, Saito T, Kaneoka H. Membranoproliferative glomerulonephritis-like glomerular disease and concurrent tubulointerstitial nephritis complicating IgG4-related autoimmune pancreatitis. Intern Med 2009; 48:157-162.

http://dx.doi.org/10.2169/internalmedicine.48.1339

[
Pubmed]   

36. Naitoh I, Nakazawa T, Ohara H, Sano H, Ando T, Hayashi K, Tanaka H, Okumura F, Miyabe K, Yoshida M, Takahashi S, Joh T. Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. Intern Med 2009; 48:2003-2007.

http://dx.doi.org/10.2169/internalmedicine.48.2695

[
Pubmed]   

37. Katano K, Hayatsu Y, Matsuda T, Miyazaki R, Yamada K, Kawano M, Takahashi N, Kimura H, Yoshida H. Endocapillary proliferative glomerulonephritis with crescent formation and concurrent tubulointerstitial nephritis complicating retroperitoneal fibrosis with a high serum level of IgG4. Clin Nephrol 2007; 68:308-314.

http://dx.doi.org/10.5414/CNP68308

[
Pubmed]   

38. Sharma SG, Vlase HL, D'Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis, 2013;61:638-43.

http://dx.doi.org/10.1053/j.ajkd.2012.07.031

[
Pubmed]   

39. Khosroshahi A, Stone JH. Treatment approaches to IgG4-related systemic disease. Curr Opin Rheumatol 2011; 23:67-71.

http://dx.doi.org/10.1097/BOR.0b013e328341a240

[
Pubmed]   

40. Khosroshahi A, Carruthers MN, Deshpande V, Unizony S, Bloch DB, Stone JH. Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients. Medicine (Baltimore) 2012; 91: 57-66.

http://dx.doi.org/10.1097/MD.0b013e3182431ef6

[
Pubmed]   

41. Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, Homma N, Tsubata Y, Takahashi H, Ito T, Yamazaki H, Saito T, Narita I. The clinical course of patients with IgG4-related kidney disease. Kidney Int 2013; 84: 826-833.

http://dx.doi.org/10.1038/ki.2013.191

[
Pubmed]   

42. Coffin CMFJ. Inflammatory myofibroblastic tumour. In: Christopher DM, Fletcher KKU, Mertens F, editors. Pathology and genetics of tumours of soft tissue and bone. Lyon, IARC Press, pp 91-93, 2002.


43. Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 2008;61:428-437.

http://dx.doi.org/10.1136/jcp.2007.049387

[
Pubmed]   

44. Zen Y, Fujii T, Sato Y, Masuda S, Nakanuma Y. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease. Mod Pathol 2007;20:884-894.

http://dx.doi.org/10.1038/modpathol.3800836

[
Pubmed]   

45. Tsuboi H, Inokuma S, Setoguchi K, Shuji S, Hagino N, Tanaka Y, Yoshida N, Hishima T, Kamisawa T. Inflammatory pseudotumors in multiple organs associated with elevated serum IgG4 level: recovery by only a small replacement dose of steroid. Intern Med 2008;47: 1139-1142.

http://dx.doi.org/10.2169/internalmedicine.47.0887

[
Pubmed]   

46. Zen Y, Kasahara Y, Horita K, Miyayama S, Miura S, Kitagawa S, Nakanuma Y. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level: histologic similarity to sclerosing pancreatitis. Am J Surg Pathol 2005;29:275-278.

http://dx.doi.org/10.1097/01.pas.0000147399.10639.f5

[
Pubmed]   

47. Zen Y, Kitagawa S, Minato H, Kurumaya H, Katayanagi K, Masuda S, Niwa H, Fujimura M, Nakanuma Y. IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung. Hum Pathol 2005;36:710-717.

http://dx.doi.org/10.1016/j.humpath.2005.05.011

[
Pubmed]   

48. Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011;42:1178-1184.

http://dx.doi.org/10.1016/j.humpath.2010.03.011

[
Pubmed]   

49. Marando A, D'Ambrosio G, Catanzaro F, La Rosa S, Sessa F. IgG4-related disease of the ureter: report of two cases and review of the literature. Virchows Arch 2013;462:673-678.

http://dx.doi.org/10.1007/s00428-013-1421-5

[
Pubmed]   

50. Abe H, Morikawa T, Araki A, Shima T, Nakatsu H, Fukayama M, Suzuki Y. IgG4-related periureteral fibrosis presenting as a unilateral ureteral mass. Pathol Res Pract 2011;207:712-714.

http://dx.doi.org/10.1016/j.prp.2011.08.003

[
Pubmed]   

51. Kim S, Kim TG, Choi SK, Kim MJ, Min GE, Lee HL, Yoo KH. Immunoglobulin g4-related systemic sclerosing disease: a case involving the ureter and kidney. Korean J Urol 2013;54:209-211.

http://dx.doi.org/10.4111/kju.2013.54.3.209

[
Pubmed]    [PMC Free Fulltext]   

52. Hamano H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, Nakazawa K, Shimojo H, Kiyosawa K. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet 2002; 359:1403–1404.

http://dx.doi.org/10.1016/S0140-6736(02)08359-9


53. Kamisawa T, Chen PY, Tu Y, Nakajima H, Egawa N. Autoimmune pancreatitis metachronously associated with retroperitoneal fibrosis with IgG4-positive plasma cell infiltration. World J Gastroenterol 2006; 12: 2955-2957.

[
Pubmed]   

54. Corradi D, Maestri R, Palmisano A, Bosio S, Greco P, Manenti L, Ferretti S, Cobelli R, Moroni G, Dei Tos AP, Buzio C, Vaglio A. Idiopathic retroperitoneal fibrosis: clinicopathologic features and differential diagnosis. Kidney Int 2007; 72: 742-753.

http://dx.doi.org/10.1038/sj.ki.5002427

[
Pubmed]   

55. Zen Y, Onodera M, Inoue D, Kitao A, Matsui O, Nohara T, Namiki M, Kasashima S, Kawashima A, Matsumoto Y, Katayanagi K, Murata T, Ishizawa S, Hosaka N, Kuriki K, Nakanuma Y. Retroperitoneal fibrosis: a clinicopathologic study with respect to immunoglobulin G4. Am J Surg Pathol 2009; 33:1833–1839.

http://dx.doi.org/10.1097/PAS.0b013e3181b72882

[
Pubmed]   

56. Park S, Ro JY, Lee DH, Choi SY, Koo H. Immunoglobulin G4–associated inflammatory pseudotumor of urinary bladder: a case report. Ann Diagn Pathol 2013;17:540-543.

http://dx.doi.org/10.1016/j.anndiagpath.2013.01.004

[
Pubmed]   

57. Crumley S, Ge Y, Zhou H, Shen SS, Ro JY. Interstitial cystitis: another IgG4-related inflammatory disease? Ann Diagn Pathol 2013;17:403-407.

http://dx.doi.org/10.1016/j.anndiagpath.2013.03.004

[
Pubmed]   

58. Choi JW, Kim SY, Moon KC, Cho JY, Kim SH. Immunoglobulin G4- related sclerosing disease involving the urethra: case report. Korean J Radiol 2012;13:803-807.

http://dx.doi.org/10.3348/kjr.2012.13.6.803

[
Pubmed]    [PMC Free Fulltext]   

59. Williamson SR, Scarpelli M, Lopez-Beltran A, Montironi R, Conces MR, Cheng L. Urethral caruncle: a lesion related to IgG4-associated sclerosing disease? J Clin Pathol 2013; 66:559-562.

http://dx.doi.org/10.1136/jclinpath-2012-201218

[
Pubmed]   

60. Yoshimura Y, Takeda S, Ieki Y, Takazakura E, Koizumi H, Takagawa K. IgG4-associated prostatitis complicating autoimmune pancreatitis. Intern Med 2006; 45: 897-901.

http://dx.doi.org/10.2169/internalmedicine.45.1752

[
Pubmed]   

61. Nishimori I, Kohsaki T, Onishi S Shuin T, Kohsaki S, Ogawa Y, Matsumoto M, Hiroi M, Hamano H, Kawa S. IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis. Intern Med 2007; 46: 1983-1989.

http://dx.doi.org/10.2169/internalmedicine.46.0452

[
Pubmed]   

62. Uehara T, Hamano H, Kawakami M Koyama M, Kawa S, Sano K, Honda T, Oki K, Ota H. Autoimmune pancreatitis-associated prostatitis: distinct clinicopathological entity. Pathol Int 2008; 58: 118-125.

http://dx.doi.org/10.1111/j.1440-1827.2007.02199.x

[
Pubmed]   

63. Hart PA,Smyrk TC, Chari ST. IgG4-related prostatitis: a rare cause of steroid-responsive obstructive urinary symptoms. Int J Urol 2013; 20:132-134.

http://dx.doi.org/10.1111/j.1442-2042.2012.03194.x

[
Pubmed]   

64. Bösmüller H, von Weyhern CH, Adam P, Alibegovic V, Mikuz G, Fend F. Paratesticular fibrous pseudotumor – an IgG4-related disorder? Virchows Arch 2011; 458: 109-113.

http://dx.doi.org/10.1007/s00428-010-0995-4

[
Pubmed]   

65. Hart PA, Moyer AM, Yi ES, Hogan MC, Pearson RK, Chari ST. IgG4-related paratesticular pseudotumor in a patient with autoimmune pancreatitis and retroperitoneal fibrosis: an extrapancreatic manifestation of IgG4-related disease. Hum Pathol 2012;43:2084-2087.

http://dx.doi.org/10.1016/j.humpath.2012.05.017

[
Pubmed]   

How to Cite this Article
Pubmed Style

Divatia MK, Ro JY. IgG4-related Disease of the Genitourinary Tract. J Interdiscipl Histopathol. 2014; 2(1): 3-18. doi:10.5455/jihp.20131224121618


Web Style

Divatia MK, Ro JY. IgG4-related Disease of the Genitourinary Tract. http://www.jidhp.com/?mno=49298 [Access: January 23, 2018]. doi:10.5455/jihp.20131224121618


AMA (American Medical Association) Style

Divatia MK, Ro JY. IgG4-related Disease of the Genitourinary Tract. J Interdiscipl Histopathol. 2014; 2(1): 3-18. doi:10.5455/jihp.20131224121618



Vancouver/ICMJE Style

Divatia MK, Ro JY. IgG4-related Disease of the Genitourinary Tract. J Interdiscipl Histopathol. (2014), [cited January 23, 2018]; 2(1): 3-18. doi:10.5455/jihp.20131224121618



Harvard Style

Divatia, M. K. & Ro, J. Y. (2014) IgG4-related Disease of the Genitourinary Tract. J Interdiscipl Histopathol, 2 (1), 3-18. doi:10.5455/jihp.20131224121618



Turabian Style

Divatia, Mukul K., and Jae Y Ro. 2014. IgG4-related Disease of the Genitourinary Tract. Journal of Interdisciplinary Histopathology, 2 (1), 3-18. doi:10.5455/jihp.20131224121618



Chicago Style

Divatia, Mukul K., and Jae Y Ro. "IgG4-related Disease of the Genitourinary Tract." Journal of Interdisciplinary Histopathology 2 (2014), 3-18. doi:10.5455/jihp.20131224121618



MLA (The Modern Language Association) Style

Divatia, Mukul K., and Jae Y Ro. "IgG4-related Disease of the Genitourinary Tract." Journal of Interdisciplinary Histopathology 2.1 (2014), 3-18. Print. doi:10.5455/jihp.20131224121618



APA (American Psychological Association) Style

Divatia, M. K. & Ro, J. Y. (2014) IgG4-related Disease of the Genitourinary Tract. Journal of Interdisciplinary Histopathology, 2 (1), 3-18. doi:10.5455/jihp.20131224121618





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  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

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  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
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    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

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  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

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